Alternatives to Laboratory Animals (ATLA) is an established peer-reviewed journal dedicated to the Three Rs — the reduction, refinement and replacement of animals in research and testing. For over 50 years, ATLA has been supporting the development, validation and novel application of New Approach Methodologies (NAMs) and encourages submissions relating to recent developments in these areas. In addition to replacement, the journal also features research that aims to reduce or refine in vivo experiments that are still carried out, as well as advocating for changes to global animal use policies.